Experimental rhinovirus infection safely induces a mild asthma exacerbation in moderate asthmatics on inhaled steroids http://ow.ly/sN04P
نویسندگان
چکیده
Peter T. Adura, Eleanor Reed, Jonathan Macintyre, Ajerico del Rosario, James Roberts, Rachel Pestridge, Rona Beegan, Christine B. Boxall, Chang Xiao, Tatiana Kebadze, Juliya Aniscenko, Victoria Cornelius, James E. Gern, Phillip D. Monk, Sebastian L. Johnston and Ratko Djukanović Clinical and Experimental Sciences, Southampton NIHR Respiratory Biomedical Research Unit, University of Southampton Faculty of Medicine, Southampton, Synairgen Research Ltd, Southampton, and National Heart and Lung Institute and Centre for Respiratory Infections, Imperial College, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College NHS Trust NIHR Comprehensive Biomedical Research Centre, London, UK. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
منابع مشابه
Spirometry Findings Following Treatment with Oral and Inhalant Corticosteroids in Mild to Moderate Asthma Exacerbation in Children
Introduction: Asthma exacerbation is common in children. Treatment with oral corticosteroids (OCS) and inhaled corticosteroids are suggested for asthma exacerbation. It is shown that inhaled corticosteroids has similar outcome in reducing asthma symptoms compared to OCS. But few studies have evaluated the pulmonary function changes in these two treatments. In this study, we evaluated the chang...
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BACKGROUND Interleukin-5 (IL-5) is thought to play a pivotal role in the pathogenesis of asthma. High levels of circulating IL-5 have been documented in acute asthma. However, serum IL-5 levels in mild to moderate asthmatics and the influence of regular use of inhaled glucocorticoids, is not known. METHODS Fifty-six asthmatics and 56 age and sex matched controls were recruited prospectively f...
متن کاملPathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma.
BACKGROUND Respiratory infections are well known triggers of asthma exacerbations, but their role in stable adult asthma remains unclear. METHODS 103 asthmatics and 30 control subjects were enrolled in the study. Sputum was induced by inhalation of 3% NaCl solution. Oropharyngeal swab specimens were obtained from the posterior wall of the oropharynx. Respiratory specimens were analysed by RT-...
متن کاملA Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13)
BACKGROUND Rhinovirus infection is a major cause of asthma exacerbations. OBJECTIVES We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. METHODS We used nasosorption on days 0, 2-5 and 7 and bronchosorption at baseline and day 4 to sample mucosal lining fluid to investigate airway mucosal responses to rhinovirus infectio...
متن کاملAsthma exacerbations . 1: epidemiology.
Asthma exacerbations may be triggered by a number of atmospheric and domiciliary environmental factors as well as by those encountered in schools and workplaces. The majority of exacerbations, particularly in children, coincide with respiratory viral infections, most commonly rhinovirus. As most respiratory viruses and many aeroallergens appear in seasonal patterns, asthma exacerbations, partic...
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